February 2021

Carrageenan containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures
Desiree Schütz, Carina Conzelmann, Giorgio Fois, Rüdiger Groß, Tatjana Weil, Lukas Wettstein, Steffen Stenger, Alexander Zelikin, Thomas Hoffmann, Manfred Frick, Janis Müller, and Jan Münch.
American Journal of Physiology-Lung Cellular and Molecular Physiology. In press


SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A.
Nature Metabolism, pages 149-165 (2021) Feb 3
December 2020
Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA
Michel D, Danzer KM, Groß R, Conzelmann C, Müller JA, Freischmidt A, Weishaupt JH, Heller S, MünchJ, Michel M, Stamminger T, Kleger A, Otto M.
J Virol Methods. 2020 Dec;286:113965. doi: 10.1016/j.jviromet.2020.113965. Epub 2020 Sep 3.
November 2020
Peptide and peptide-based inhibitors of SARS-CoV-2 entry
Schütz D, Ruiz-Blanco YB, MünchJ, Kirchhoff F, Sanchez-Garcia E, Müller JA.
Adv Drug Deliv Rev. 2020 Nov 13;167:47-65. doi: 10.1016/j.addr.2020.11.007.
 
Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids
Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, MünchJ, Kleger A.
Cell Mol Gastroenterol Hepatol. 2020 Nov 10 : S2352-345X(20)30182-X.
October 2020
Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro
Bruno Frank, Carina Conzelmann, Tatjana Weil, Rüdiger Groß, Peggy Jungke, Maren Eggers, Janis A. Müller, Jan Münch, Uwe Kessler. 
bioRxiv 2020.10.30.360545; doi: https://doi.org/10.1101/2020.10.30.360545
    
SARS-CoV-2 infects cells of the human exocrine and endocrine pancreas and interferes with beta-cell function
Janis A Müller, Rüdiger Groß, Carina Conzelmann, Jana Krüger, Lennart Koepke, Johannes Steinhart, Tatjana Weil, Caterina Prelli Bozzo, Clarissa Read, Giorgio Fois, Tim Eiseler, Julia Gehrmann, Joanne van Vuuren, Isabel M Wessbecher, Manfred Frick, Ivan G Costa, Markus Breunig, Michael Schuster, Stefan Liebau, Thomas Seufferlein, Steffen Stenger, Albrecht Stenzinger, Patrick E MacDonald, Frank Kirchhoff, Konstantin MJ Sparrer, Paul Walther, Heiko Lickert, Thomas FE Barth, Martin Wagner, Jan Münch, Sandra Heller, Alexander Kleger.
23 October 2020, PREPRINT (Version 1)  https://doi.org/10.21203/rs.3.rs-96076/v1

 

Imperfect innate immune antagonism renders SARS-CoV-2 vulnerable towards IFN-γ and -λ

Manuel Hayn, Maximilian Hirschenberger, Lennart Koepke, Jan H Straub, Rayhane Nchioua, Maria H Christensen, Susanne Klute, Caterina Prelli Bozzo, Wasim Aftab, Fabian Zech, Carina Conzelmann, Janis A Müller, Smitha Srinivasachar Badarinarayan, Christina M Stürzel, Ignasi Forne, Steffen Stenger, Karl-Klaus Conzelmann, Jan Münch, Daniel Sauter, Florian I Schmidt, Axel Imhof, Frank Kirchhoff, Konstantin MJ Sparrer.
bioRxiv 2020.10.15.340612; doi: https://doi.org/10.1101/2020.10.15.340612
 
Undermining breastfeeding will not alleviate the COVID-19 pandemic
Groß R, Conzelmann C, Müller JA, Reister F, Kirchhoff F, Münch
Lancet. 2020 Oct 10;396(10257):1065-1066. doi: 10.1016/S0140-6736(20)32066-3.
 
Systematic analysis of innate immune antagonism reveals vulnerabilities of SARS-CoV-2
Manuel Hayn, Maximilian Hirschenberger, Lennart Koepke, Jan H Straub, Rayhane Nchioua, Susanne Klute, Caterina Prelli Bozzo, Wasim Aftab,Fabian Zech, Carina Conzelmann, Janis A Müller, Smitha Srinivasachar Badarinarayan, Christina M Stürzel, Ignasi Forne, Steffen Stenger, Karl-Klaus Conzelmann, Jan Münch, Daniel Sauter, Axel Imhof, Frank Kirchhoff, Konstantin MJ Sparrer 
bioRxiv 2020.10.15.340612; doi: https://doi.org/10.1101/2020.10.15.340612
 
SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans
Rayhane Nchioua, Dorota Kmiec, Janis A. Müller, Carina Conzelmann, Rüdiger Groß, Chad M. Swanson, Stuart J. D. Neil, Steffen Stenger, Daniel Sauter, Jan Münch, Konstantin M. J. Sparrer, Frank Kirchhoff
mBio Oct 2020, 11 (5) e01930-20; DOI: 10.1128/mBio.01930-20
 
Pasteurization Inactivates SARS-CoV-2 Spiked Breast Milk
Carina Conzelmann, Rüdiger Groß, Toni Luise Meister, Daniel Todt, Adalbert Krawczyk, Ulf Dittmer, Steffen Stenger, Jan Münch, Eike Steinmann, Janis A Müller and Stephanie Pfaender
Pediatrics Oct 2020, e2020031690; DOI: 10.1542/peds.2020-031690
September 2020
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers
Weil T, Groß R, Röcker A, Bravo-Rodriguez K, Heid C, Sowislok A, Le MH, Erwin N, Dwivedi M, Bart S, Bates P, Wettstein L, Müller J, Harms M, Sparrer K, Ruiz-Blanco YB, Stuerzel C, von Einem J, Lippold S, Read C, Walther P, Hebel M, Kreppel F, Klärner FG, Bitan G, Ehrmann M, Weil T, Winter R, Schrader T, Shorter J, Sanchez-Garcia E, Muench J.
J Am Chem Soc. 2020 Sep 14. doi: 10.1021/jacs.0c06400

 

Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2
Meister TL, Brüggemann Y, Todt D, Conzelmann C, Müller JA, Groß R, Münch J, Krawczyk A, Steinmann J, Steinmann J, Pfaender S, Steinmann E. Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2.
J Infect Dis. 2020 Sep 14;222(8):1289-1292. doi: 10.1093/infdis/jiaa471
Errata as per 3 October 2020
August 2020
IFITM proteins promote SARS-CoV-2 infection of human lung cells
Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lukas Wettstein, Tatjana Weil, Jana Krüger, Sandra Heller, 
Carina Conzelmann, Janis Müller, Rüdiger Gross, Fabian Zech, Desiree Schütz, Lennart Koepke, ChristinaM Stuerzel, Christiane Schüler, Saskia Stenzel, Elisabeth Braun, Johanna Weiß, Daniel Sauter, Jan Münch, Steffen Stenger, Kei Sato, Alexander Kleger, Christine Goffinet, Konstantin M.J. Sparrer, Frank Kirchhoff
bioRxiv 2020.08.18.255935; doi: https://doi.org/10.1101/2020.08.18.255935

 

Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19
Carina Conzelmann, Janis A Müller, Lukas Perkhofer, Konstantin MJ Sparrer, Alexander N Zelikin, Jan Münch and Alexander Kleger
Clinical Medicine Aug 2020, 2020-0351; DOI: 10.7861/clinmed.2020-0351

Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA
Detlef Michel,  Karin M. Danzer, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Axel Freischmidt, Jochen  Weishaupt,  Sandra Heller, Jan Münch, Manuela Michel, Thomas Stamminger, Alexander Kleger, Markus Otto
Journal of Virological Methods, Volume 286, 2020, 113965, ISSN 0166-0934

Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection
Carina Conzelmann , Rüdiger Groß , Min Zou , Franziska Krüger , AndréGörgens , Manuela O Gustafsson , Samir El Andaloussi , Jan Münch & Janis A.Müller
Journal of Extracellular Vesicles, 9:1, DOI: 10.1080/20013078.2020.18082811
July 2020
An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection
Conzelmann C, Gilg A, Groß R, Schütz D, Preising N, Ständker L, Jahrsdörfer B, Schrezenmeier H, Sparrer KMJ, Stamminger T, Stenger S, Münch J, Müller JA.
Antiviral Res. 2020 Jul 29;181:104882. doi: 10.1016/j.antiviral.2020.104882. 
bioRxiv 2020.06.14.150862; doi: https://doi.org/10.1101/2020.06.14.150862

Alpha-1 antitrypsin inhibits SARS-CoV-2 infection
Lukas Wettstein, Carina Conzelmann, Janis A. Müller, Tatjana Weil, Rüdiger Groß, Maximilian 
Hirschenberger
, Alina Seidel, Susanne Klute, Fabian ZechCaterina Prelli Bozzo, Nico Preising,
Giorgio Fois, Robin Lochbaum, Philip Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, 
Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Konstantin Sparrer,
Frank Kirchhoff, Manfred Frick, Jan Münch
bioRxiv 2020.07.02, https://doi.org/10.1101/2020.07.02.183764
June 2020
Remdesivir but not famotidine inhibits SARS-CoV-2 replication in human pluripotent stem cell-derived intestinal organoids
Jana Krüger, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Lennart Koepke, 
Konstantin M. J. Sparrer, Desiree Schütz, Thomas Seufferlein, Thomas F.E. Barth, Steffen Stenger, 
Sandra Heller, Alexander Kleger, Jan Münch
bioRxiv 2020.06.10.144816; doi: https://doi.org/10.1101/2020.06.10.144816

The Zinc Finger Antiviral Protein restricts SARS-CoV-2
Rayhane Nchioua, Dorota Kmiec, Janis Müller, Carina Conzelmann, Rüdiger Groß, Chad Swanson, Stuart Neil, Steffen Stenger, Daniel Sauter, Jan Münch, Konstantin M. J. Sparrer, Frank Kirchhoff
bioRxiv 2020.06.04.134379; doi: https://doi.org/10.1101/2020.06.04.134379

Holder Pasteurization Inactivates SARS-CoV-2 in Human Breast Milk
Carina Conzelmann, Rüdiger Groß, Toni Luise Meister, Daniel Todt, Adalbert Krawczyk, Ulf Dittmer, 
Steffen Stenger, Jan Münch, Eike Steinmann, Janis A Müller, Stephanie Pfaender
bioRxiv 2020.06.17.155689; doi: https://doi.org/10.1101/2020.06.17.155689
May 2020
Detection of SARS-CoV-2 in Human Breast Milk
Rüdiger Groß, Carina Conzelmann, Janis A Müller, Steffen Stenger, Karin Steinhart, Frank Kirchhoff and Jan Münch
The Lancet, Volume 395, Issue 10239, 2020, Pages 1757-1758, ISSN 0140-6736

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates
Pauline Maisonnasse, Jérémie Guedj, Vanessa Contreras, Sylvie Behillil, Caroline Solas, Romain Marlin, Thibaut Naninck, Andres Pizzorno, Julien Lemaitre, Antonio Gonçalves, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fan, Vincent Enouf, Nathalie Dereuddre- Bosquet, Angela Brisebarre, Franck Toure, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Sylvie van der Werf, Xavier de Lamballerie, Roger Le Grand
Nature 585, 584–587 (2020). https://doi.org/10.1038/s41586-020-2558-4
Transmission electron microscopic image of an isolate from the first U.S. case of COVID-19, formerly known as 2019-nCoV. The spherical extracellular viral particles contain cross-sections through the viral genome, seen as black dots. Photo credit to CDC/ Cynthia S. Goldsmith and A. Tamin
The Fight-nCoV Consortium Office, Dept. of Molecular Bioscience,
The Wenner-Gren Institute (MBW), Stockholm University, S-106 91 Stockholm, Sweden
 
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 101003555. The sole responsibility for the content lies with the authors, and does not necessarily reflect the opinion of the European Union.